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Acta Pharmaceutica Indonesia Vol. 43 Issue 1 2018

Vol. 43 No. 1 (2018)

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Articles Published in This Issue

Explore peer-reviewed research articles published in this issue.

researchpp. 1–6

Pengembangan Metode Penentuan Kadar ZnO dalam Bedak Wajah Menggunakan Spektroskopi Serapan Atom

Seng (Zn) dalam bentuk seng oksida (ZnO) merupakan bahan tabir surya yang terdapat dalam berbagai kosmetik antara lain dalam produk bedak. ZnO apabila berpenetrasi ke dalam kulit dalam jumlah berlebih dapat menyebabkan terjadinya fotosensitisasi sehingga penggunaannya di dalam kosmetik dibatasi oleh pemerintah. Tujuan dari penelitian ini adalah untuk mengembangkan metode penentuan kadar Zn dalam bedak dan menggunakannya untuk penentuan kadar Zn dalam beberapa sampel bedak yang beredar di Indonesia dengan menggunakan spektroskopi serapan atom (SSA). Persamaan linearitas metode dari hasil…

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researchpp. 15–21

The Off-Label Use of Oxcarbazepine In Indonesia

Oxcarbazepine is a second-generation anticonvulsant drug that is a keto analog of carbamazepine. Oxcarbazepine was approved by The National Agency of Drug and Food Control Indonesia (NA-DFC) for generalized epilepsy, tonic-clonic primary and partial epilepsy with or without secondary generalization. However, as other anticonvulsants, oxcarbazepine is also often used without approved indication (off-label). The aim of this study is to investigate the off-label use of oxcarbazepine through an observational study with retrospective data collection. Data were obtained from four hospitals in…

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researchpp. 22–28

Analysis of Health-related Quality of Life Determinants in Adult Ashmatic Patients in a District Hospital in East Jakarta

Background: Uncontrolled asthma leads to patients' poor outcomes and decreases health-related quality of life/HRQoL. Little research has been done to analyze the determinants of HRQoL in asthmatics patients. Objective: To determine asthma control and patients' compliance levels, and evaluate the appropriateness of medicine use and determinants of HRQoL. Methods: During this prospective study, adult asthmatic patients who currently experienced asthma attack were evaluated in asthma clinic of a district hospital in Jakarta and administered study questionnaires. Demographic variables and data…

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researchpp. 29–33

Determination of sun protective factors (SPF) and antioxidant activity of ethanolic extract of rambutan rind (Nephelium lappaceum L.)

Background, The fruit peels of rambutan (Nephelium lappaceum L)are organic garbage with many potential health benefits but have not been used optimally. Purposes This study aims to determine the sun protective factor (SPF) and antioxidant activity of ethanolic extract of rambutan rind. Methods The rambutan (Nephelium lappaceum L) rind was extracted by maceration method using ethanol as solvent. A simple, rapid and reliable in vitro method was used to assess the SPF values by measuring the absorbance of diluted extract between 290-320 nm at every 5 nm intervals using Ultraviolet…

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researchpp. 7–14

ISOLASI SENYAWA MARKER DARI EKSTRAK AIR DAUN KELOR (MORINGAN OLEIFERA LAMK.)

Kelor (MoringaoleiferaLamk.) adalah tanaman termasuk dalam famili Moringaceae yang telah lama digunakan dalam pengobatan beberapa penyakit secara tradisional. Penggunaan secara empiris tersebut telah dibuktikan secara ilmiah. Penelitian ini bertujuan untuk mengisolasi senyawa marker dari ekstrak air daun kelor. Penelitian ini dimulai dari pembuatan ekstrak, karakterisasi simplisia, dan penapisan fitokimia. Pembuatan ekstrak dilakukan dengan cara daun diblender dengan penambahan aquades kemudian disaring. Filtrat yang diperoleh dikumpulkan, kemudian dikeringkan menggunakanalat freeze dryer…

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