Vol. 57 No. 2 (2025)

Leukemia is caused by abnormal white blood cell proliferation that leads to disruption of conventional blood cell functions. Mangosteen (Garcinia mangostana L.) contains phytochemical compounds with strong anticancer properties, according to various cancer studies. This study investigated the potential of mangosteen peel extract (MPE) as an anti-leukemia agent through molecular docking of LC-MS-identified compounds against FLT-1 and AKT proteins, followed by in vitro evaluation on HL-60 cells, namely cytotoxic (WST-8 assay), ROS levels and senescence (flow cytometry), and then FLT1 and AKT…

Baker’s yeast naturally occurs in plant materials with high glucose content, including sugarcane (Saccharum officinarum L.). This study aimed to isolate and identify yeast from sugarcane juice and evaluate its safety and potential application as baker’s yeast. The methodological workflow included isolation, purification, macroscopic and microscopic characterization, and molecular identification. Safety assessments consisted of hemolysis testing and the evaluation of phospholipase and protease enzyme activities. The technological potential of the isolates was examined through carbohydrate…

We propose a robust multi-stage compartmental model to studytuberculosis (TB) transmission dynamics in Namibia, incorporating multiple stagesof latent infection, along with undiagnosed and diagnosed active cases. The modeldistinguishes between early and late latent stages, allowing for a more accuraterepresentation of TB progression. By capturing the complex interactions betweendisease progression, diagnosis, treatment, and relapse, the model provides valuableinsights into TB dynamics. Mathematical analyses and key simulation parametersare discussed, offering a framework that can inform…

Three triterpenoid compounds, belonging to the penta- and tetracyclic groups, were successively isolated from the stembark of Aglaia cucullata and identified as b-amyron (1), dammaradienon (2), and cabralealactone (3). After extensive extraction, chromatographic separation and purification, compounds 1 to 3 were gained. Spectroscopic analysis in addition to HRMS, FTIR, 1D and 2D NMR analysis were utilized to determine the chemical structure. After that, compounds 1 to 3 were tested against breast cancer, melanoma as well as normal kidney cells (MCF-7, B16-F10, and CV-1, respectively). The…

Increasing performance of supercapacitors can be achieved by using a composite of electrode materials. Nevertheless, selecting appropriate materials and determining the optimal combination composition remain significant challenges. In this research, a ternary composite of MnO2/polyaniline (PANI)/Maxsorb was studied. The combination of Maxsorb, PANI, and MnO₂ is a unique feature of this research, with Maxsorb acting as a porous structural framework; PANI enhancing electrical conductivity; and MnO₂ providing high pseudocapacitance. The ternary material was prepared by impregnation of MnO2 and…