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Acta Pharmaceutica Indonesia Vol. 47 Issue 2 2022

Vol. 47 No. 2 (2022)

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Articles Published in This Issue

Explore peer-reviewed research articles published in this issue.

researchpp. 1–8

AKTIVITAS ANTIINFLAMASI INFUSA BAWANG PUTIH SEGAR DAN BAWANG HITAM (Allium sativum L.) PADA TIKUS PUTIH (Rattus norvegicus L.)YANG DIINDUKSI KARAGENAN

Inflamasi merupakan respon perlindungan normal terhadap berbagai kerusakan pada jaringan. Pengobatan inflamasi jangka panjang dapat menimbulkan berbagai macam efek samping sehingga diperlukan pengembangan antiinflamasi yang berasal dari bahan alam sebagai alternatif pilihan pengobatan. Bawang putih (Allium sativum L.) secara tradisional digunakan untuk mengobati diabetes, kolesterol, dan tekanan darah tinggi serta terbukti memiliki aktivitas sebagai antiinflamasi. Bawang hitam merupakan olahan lain dari bawang putih yang dikembangkan untuk mengurangi rasa dan bau yang tak sedap dari bawang…

Keywords
bawang putih inflamasi bawang hitam antiinflamasi karagenan
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researchpp. 16–27

ANALYSIS OF POTENTIAL COMPOUNDS FROM JAVANESE GINSENG (TALINUM PANICULATUM GAERTN.) AND KELOR LEAVES (MORINGA OLEIFERA) AS THE ANTI-INFLAMMATION WITH MOLECULAR DOCKING METHOD

Inflammation is the immune system's response to noxious stimuli such as pathogens, damaged cells, toxic compounds, or radiation. It often causes pain or discomfort. In this study, the search for potential compounds as COX-2 inhibitors from javanese ginseng (Talinum paniculatum Gaertn.) and moringa (Moringa oleifera) was carried out. The method used in this research was molecular docking by the Molegro Virtual Docker. Some assessments that have been done in this research are Rerank Score, Hbond interaction, and Lipinski Rule of Five. The result showed that COX-2 inhibitor compounds potential…

Keywords
Moringa oleifera Talinum paniculatum molecular docking antiinflammation Molegro virtual docker
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reviewpp. 28–45

CASE REPORT STUDIES OF ADVERSE EFFECTS POST COVID-19 VACCINATION: A NARRATIVE REVIEW

The accelerated Covid-19 vaccines’ emergency use authorization raises many questions regarding the safety and effectiveness of the vaccine due to the short duration of the pre-marketing clinical trial phase. In terms of vaccine safety, longer studies are needed, especially to see if there are long-term effects or unusual effects that were not detected during pre-marketing clinical trials. This study aims to summarize and assess the adverse reactions that occur after the administration of the Covid-19 vaccine that has obtained approval for emergency use. The search for case reports was carried…

Keywords
adverse effect case report Covid-19 pharmacovigilance post-vaccination vaccine safety
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researchpp. 46–62

IMPACT OF ADVERTISEMENT TOWARDS FERTILE AGED WOMEN PERCEPTION AND BEHAVIOR IN DYSMENORRHEA TREATMENT

Dysmenorrhea is menstrual pain that often experienced by women of reproductiveage; therefore, it is crucial to obtain information about its therapy. Advertisement isone of the ways to deliver information about dysmenorrhea. This study aimed toevaluate the influence of advertisements on women at reproductive age’s perceptionand behavior in overcoming dysmenorrhea. It is also aimed to see the influence ofdemographic characteristics on respondents’ perceptions and behavior, and thepotential role of health workers to ensure proper information of dysmenorrheatherapy. The study apply a…

Keywords
iklan dismenorea persepsi perilaku
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researchpp. 9–15

Formulasi Dan Evaluasi Fisik Sediaan Spray Ekstrak Daun Kemangi (Ocimum x africanum Lour.) Sebagai Repellan Alami Terhadap Nyamuk Aedes aegypti

ABSTRAK. 
 Daun kemangi mengandung senyawa yang memiliki manfaat sebagai penolak terhadap nyamuk Aedes aegypti (repellan). Tujuan dari penelitian ini adalah untuk mengetahui mengetahui konsentrasi yang baik dalam formulasi sediaan spray ekstrak daun kemangi (Ocimum x africanum Lour.) sebagai repellan dengan variasi konsentrasi propilenglikol. Metode ekstraksi dalam penelitian ini menggunakan perkolasi dengan pelarut Etil asetat. Hasil ekstraksi diformulasikan dalam sediaan spray, kemudian diuji efektivitas anti nyamuk. Hasil ekstraksi daun kemangi diperoleh persen rendemen 10.78%. Hasil…

Keywords
daun kemangi repellent spray Aedes aegypti
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